openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
Morphomechanically-Informed Spatial Curvature Sequencing in Prostate Cancer
Ivan Kordic, Felix G. Rivera Moctezuma, Hoseyn A. Amiri, Ajie Liu, Shuangyi Cai, Mehdia Nadeem Rajab Ali, et al.
Morphological changes in prostate glands, assessed by Gleason grading, remain the gold standard for diagnosing prostate cancer, yet molecular biomarkers associated with gland shape are not well understood. Here, we introduce CurvSeq, a mechanomorphology-informed framework for spa…