semantic_scholarIEEE Photonics Journal2026-08-01
Integration of Deep Learning and Machine Learning for Label-Free Two-Photon Imaging-Based Classification of Oral Lesions: A Pilot Study
Manikanth Karnati, Jackson Rodrigues, Gagan Raju, Edwin Pious, Vathsala Patil, A. Kudva, et al.
TL;DR: An integrated pipeline combining TPF imaging with ConvNeXt-Small network-based feature extraction and machine learning classification is proposed for rapid, objective, and label-free screening of oral lesions.
Early and objective diagnosis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) remains challenging due to limitations in conventional histopathology, including sampling bias, staining variability, and subjective interpretation. Label-free mu…