openalexNature Communications2026-07-24
Cryo-EM structures of biopsy-derived TTR fibrils in hereditary transthyretin amyloidosis
Yu-Xin Zheng, Jiawei Liang, Zhenyu Li, Yixiao Liu, Xujun Chu, Shaochong Zhang, et al.
Abstract Hereditary transthyretin amyloidosis (ATTRv) is a fatal autosomal dominant disease characterized by systemic deposition of transthyretin (TTR) amyloid fibrils, leading to progressive neuropathy and cardiomyopathy. More than 130 pathogenic mutations in the TTR gene have b…