crossrefDiagnostics2026-07-16
Interpretable Machine Learning for Predicting Suboptimal 12-Month Growth Response to Recombinant Human Growth Hormone in Children with Idiopathic Short Stature: A Dual-Center External Validation Study
Chuanyu Yang, Yifeng Shao, Chengyang Jiang, Runmin Zhang, Jian Wang, Xinlin Chen, et al.
Background/Objectives: Individual responses to recombinant human growth hormone (rhGH) therapy in children with idiopathic short stature (ISS) vary substantially, limiting pretreatment decision-making. This study aimed to develop and externally validate an interpretable machine l…