openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
<i>DROSOPHILA PRICKLE</i> MUTANTS DISPLAY COMORBID NEUROLOGICAL PHENOTYPES AND PROVIDE A GENETIC LINK BETWEEN EPILEPSY AND AUTISM SPECTRUM DISORDER
Krishna M. Nukala, Brady Williquett, Anthony J. Lilienthal, Dakota M. Thompson, Josephine N. Massingham, Shu Hui Lye, et al.
Epilepsy affects approximately 30% of individuals with autism spectrum disorder (ASD). Consistent with these observations, while PRICKLE mutations are primarily linked with epilepsy, there is an enrichment of pathogenic DNA sequence variants in PRICKLE genes carried by individual…