arxivcs.LGq-bio.GN2026-07-06
Predictive single cell foundation model for gene regulation and aging with privacy-preserving tabular learning
Jiayuan Ding, Jianhui Lin, Ziyang Miao, Nils Mechtel, Shiyu Jiang, Yixin Wang, et al.
Pre-trained foundation models (FMs) have begun transforming single-cell genomics, but scaling them raises privacy concerns. Moreover, unlike text data, single-cell data is unordered and exhibits a unique tabular structure that current single-cell FMs overlook. We introduce Tabula…