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openalexZenodo (CERN European Organization for Nuclear Research)2026-07-26Cited by 0

Data and Code for: Graph convolutional network model of CD4+ T cells provides an optimal single-cell clock for human age prediction

Qingqing Hao, Jun Zhang, M H Zhao, Min Wang, Fanglin Guan, Jiangwei Yan

OverviewThis repository contains the code and processed datasets for the manuscript: “Graph convolutional network model of CD4+ T cells provides an optimal single-cell clock for human age prediction”.This study demonstrates that utilizing single-cell Graph Convolutional Networks (scGCN) with gene-gene interaction graphs from CD4+ T cells achieves optimal age prediction performance compared to traditional machine learning models. Project WorkflowPlease run the scripts in the following folders sequentially: 01_seurat_analysis: Single-cell data preprocessing using Seurat (quality control, normalization, and cell-type extraction). 02_graph_construction: Building gene-gene interaction graphs based on the STRING database. 03_age_prediction_analysis: Training and comparing five distinct age prediction models across different cell types.

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