Tamoxifen-induced retinopathy is well recognized and frequently reported in clinical practice. By contrast, ocular adverse events associated with the structurally similar agent toremifene remain rarely described. We present a case of bilateral visual impairment in a patient receiving long-term oral toremifene citrate for secondary prevention after breast cancer surgery. Ophthalmic evaluation showed yellowish-white crystalline deposits within the macular retinal layers in both eyes. Optical coherence tomography (OCT) revealed cystic vacuolization in the bilateral foveal regions, with features closely resembling tamoxifen-induced retinopathy. A clinical diagnosis of toremifene-associated retinopathy was established. This case may provide reference for clinicians when judging the appropriate timing of toremifene withdrawal. Should drug cessation be considered, a joint assessment by ophthalmologists and oncologists should be performed to balance the risks of tumor progression and ocular damage before reaching a clinical decision. In addition, this case supplements available evidence regarding toremifene-related ocular toxicity and raises clinical awareness of this condition.
Purpose To assess COVID-19’s impact on global cervical cancer burden and examine how COVID-19 vaccination rates and Human Development Index (HDI) interact to shape disease trends, with exploratory projections to 2050. Methods Using Global Burden of Disease 2023 data (1990–2023),…
Introduction Aerobic exercise is a cornerstone of chronic obstructive pulmonary disease (COPD) management; however, its association with lung function parameters has remained inconsistent across prior studies, and previous studies have been limited by examining physical activity…
Objective This study aimed to develop and validate a distinct, stable, and interpretable predictive model using machine learning techniques to identify individuals at high risk of pneumonia early after admission. The goal was to provide a potential quantitative reference for impl…
Gastrointestinal involvement is common in systemic sclerosis (SSc), but severe abdominal pain should not be attributed automatically to dysmotility or malabsorption. We report a 72-year-old woman with long-standing limited cutaneous SSc who developed recurrent severe abdominal pa…
Objective To characterize the link of the C-reactive protein-albumin-lymphocyte index (CALLY index) to preserved ratio impaired spirometry (PRISm), and to determine its incremental contribution to PRISm risk prediction in clinical practice. Methods A total of 189 participants wer…
Objectives To enhance the diagnostic and therapeutic awareness of eosinophilic granulomatosis with polyangiitis (EGPA) complicated by pulmonary aspergillosis. Methods We report a case of EGPA initially misdiagnosed as allergic bronchopulmonary aspergillosis (ABPA) in a 52-year-ol…