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Ömer Akgüller

3 papers indexed

crossrefBiomedicines2026-01-09

Hierarchical Network Organization and Dynamic Perturbation Propagation in Autism Spectrum Disorder: An Integrative Machine Learning and Hypergraph Analysis Reveals Super-Hub Genes and Therapeutic Targets

Larissa Margareta Batrancea, Ömer Akgüller, Mehmet Ali Balcı, Lucian Gaban

Background/Objectives: Autism spectrum disorder (ASD) exhibits remarkable genetic heterogeneity involving hundreds of risk genes; however, the mechanism by which these genes organize within biological networks to contribute to disease pathogenesis remains incompletely understood.…

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crossrefProcesses2025-06-19Cited by 14

Machine Learning-Driven Multi-Objective Optimization of Enzyme Combinations for Plastic Degradation: An Ensemble Framework Integrating Sequence Features and Network Topology

Ömer Akgüller, Mehmet Ali Balcı

Plastic waste accumulation presents critical environmental challenges demanding innovative circular economy solutions. This study developed a comprehensive machine learning framework to systematically identify optimal enzyme combinations for polyester depolymerization. We integra…

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crossrefDiagnostics2024-12-04Cited by 3

Functional Brain Network Disruptions in Parkinson’s Disease: Insights from Information Theory and Machine Learning

Ömer Akgüller, Mehmet Ali Balcı, Gabriela Cioca

Objectives: This study investigates disruptions in functional brain networks in Parkinson’s Disease (PD), using advanced modeling and machine learning. Functional networks were constructed using the Nonlinear Autoregressive Distributed Lag (NARDL) model, which captures nonlinear…

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