openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells
Andrew G. Farr, Jessica C. Orr, Buthainah M Ahmed, Léa Hascher, Tony Brooks, Robert E. Hynds
Age is a principal risk factor for chronic respiratory diseases. During aging, the airway epithelium undergoes structural and functional changes, including a reduced regenerative capacity. Basal cells act as stem/progenitor cells within the airway epithelium and are known to acqu…