openalexFrontiers in Immunology2026-07-24
Non-redundant functions of NFATc1 in survival and NFATc2 in generation of exhausted CD8+ T cells
Salvador Sampere-Birlanga, Stefan Klein‐Hessling, Miriam Campillo Prados, Anfei Huang, Hao Wu, Andreas Rosenwald, et al.
Persistent antigenic stimulation leads to the dysfunction of CD8 + cytotoxic T cells. These “exhausted” T EX cells exhibit reduced proliferative capacity, impaired effector function, and increased expression of co-inhibitory receptors. Chronic antigen receptor stimulation induces…