This study integrates multidimensional computational approaches—network toxicology, machine learning, molecular docking, and molecular dynamics simulation—to systematically elucidate the toxic mechanism by which the environmental pollutant diisononyl cyclohexane-1,2-dicarboxylate…
Triclosan (TCS) exposure is linked to increased acute myocardial infarction (AMI) risk, but underlying mechanisms remain unclear. Here, we integrated network toxicology, machine learning, molecular simulations, and in vitro assays to delineate this pathway. Differential expressio…
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible interstitial lung disease characterized by progressive scarring of the lungs. The available therapeutic strategies are limited and primarily focus on slowing disease progression rather than achieving fibrosis rever…