openalexFrontiers in Immunology2026-07-23
Augmenting SOFA-2 with immune markers to capture dysregulated host response in patients with suspected infection
Introduction The updated SOFA-2 score excludes the immune system due to specificity concerns, creating a conceptual gap given that sepsis is defined by a dysregulated host response. We hypothesized that augmenting SOFA-2 with widely available immune markers—white blood cell count…