crossrefMolecules2023-11-01Cited by 4
LCK-SafeScreen-Model: An Advanced Ensemble Machine Learning Approach for Estimating the Binding Affinity between Compounds and LCK Target
Ying Cheng, Cong Ji, Jun Xu, Roufen Chen, Yu Guo, Qingyu Bian, et al.
The lymphocyte-specific protein tyrosine kinase (LCK) is a critical target in leukemia treatment. However, potential off-target interactions involving LCK can lead to unintended consequences. This underscores the importance of accurately predicting the inhibitory reactions of dru…