openalexnpj Precision Oncology2026-07-26
AI-driven multi-omics integration and virtual screening identify UFC1 as a druggable effector in chemotherapy-stressed colorectal cancer
D D Xu, Jun Xu, Ying Liu, Y P Ding, Pingping Xu, D X Zhu
Chemoresistance remains a major obstacle in colorectal cancer (CRC) treatment. In this study, we performed an integrative multi-omics analysis of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets, combined with machine learning approaches, to systematicall…