arxivcs.LG2026-06-26
PerturbCellRL: Verifier-Guided Reinforcement Learning for Single-Cell Perturbation Prediction
Dongxia Wu, Mingyu Li, Yuhui Zhang, Anurendra Kumar, Emma Lundberg, Serena Yeung-Levy, et al.
Single-cell perturbation models can reduce costly wet-lab screening by predicting how cells respond transcriptionally to interventions. While recent generative models improve population-level prediction, individual generated cells are not explicitly checked for biological consist…