openalexNature Communications2026-07-24
DirectContacts2: a wiring diagram of human physical protein interactions
Erin R. Claussen, Miles D Woodcock-Girard, Susan M. Fischer, Kevin Drew
Abstract Cellular function is driven by the activity of proteins in stable complexes. Protein complex assembly depends on the direct physical association of component proteins. Advances in macromolecular structure prediction with tools like AlphaFold and RoseTTAFold have greatly…