openalexFrontiers in Pharmacology2026-07-23
Severity-stratified vasopressor-escalation strategies in septic shock: a cross-fitted doubly robust analysis with external replication
Yuhang Zhang, Menglin Han, Xiaosu Liu, Guanyu Chen, Li Zhang
Background The optimal vasopressor-escalation strategy after norepinephrine in septic shock remains uncertain, with randomized trials showing no clear winner and observational data suggesting severity-dependent effects. We characterized severity-stratified heterogeneity for addin…