openalexFrontiers in Immunology2026-07-23
Immunomodulation in the repair of osteonecrosis of the femoral head: reprogramming strategies for macrophages and immune cells
Longfei Han, Mingli Han, Wenyuan Hou, Guifeng Luo, Long Tian, M Li, et al.
Osteonecrosis of the femoral head (ONFH) is a severe and debilitating disease that substantially affects patients’ functional capacity and daily activities. Within necrotic femoral heads, immune cells, particularly macrophages, undergo phenotypic reprogramming. This phenotypic sh…