crossrefInternational Journal of Molecular Sciences2025-11-26
Multi-Pathway Mechanisms of Engeletin in Ischemic Stroke: A Comprehensive Study Based on Network Pharmacology, Machine Learning, and Immune Infiltration Analysis
Huiming Xue, Yuchen Wen, Jiahui Yang, Yue Zhang, Chang Jin, Bing Li, et al.
Ischemic stroke (IS) is a leading cause of mortality and long-term disability, underpinned by complex molecular mechanisms, such as oxidative stress, neuroinflammation, and apoptosis. The flavonoid Engeletin exhibits promising neuroprotective properties, but its mechanism of acti…