openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
Weak interactions drive selective proteome demixing and tune the differential response to environmental perturbations
Guido Narduzzi, Federico Zucca, Léo Willig, Ludovic Gillet, Ino Karemaker, Aleksander A. Rebane, et al.
The intracellular space is a crowded environment where macromolecules perform distinct tasks despite pervasive "non-specific" interactions. Whether these interactions are functionally relevant and how they influence cellular organization remains unclear. Here, we developed QuPID-…