openalexPLoS ONE2026-07-24
A 3-dimensional Resnet model for assessment of drug efficacy in 3D cancer models using optical coherence tomography
Gavrielle R. Untracht, Jan Kaminski, Eike Guldenring, Boye Schnack Nielsen, Kim Holmstrøm, Katrine Jensen, et al.
Ninety percent of drugs fail during clinical trials, mainly due to lack of clinical efficacy. Recent developments in in vitro models such as 3D tumor heterospheroids have led to improvements in failure rates, but the relative lack of standardized evaluation methods for 3D culture…