openalexFrontiers in Immunology2026-07-23
Generation and characterization of an anti ITGB4 monoclonal antibody that blocks Zika virus entry
X D Han, Weiwei Li, Shuqian Yang, Yancun Gong, Jie Shen, Lei Song, et al.
Introduction Zika virus (ZIKV) causes congenital disease and neurological complications, yet no approved vaccines or antivirals are available. Integrin β4 (ITGB4) has been identified as an entry receptor for ZIKV. Methods Recombinant human ITGB4 ectodomain was expressed using a b…