openalexJournal of Translational Medicine2026-07-24
P4HA1⁺ collagen-modifying fibroblasts are associated with pro-tumor niches and therapeutic vulnerabilities in colorectal cancer
Kai Gui, Yuehua Chen, Qinqin Du, Ke Lv, W Y Wang, Ziyun Li, et al.
Cancer-associated fibroblasts (CAFs) are a major stromal component of the tumor microenvironment (TME) and actively participate in tumor progression. Although CAF heterogeneity in colorectal cancer (CRC) is increasingly recognized, how individual CAF subpopulations simultaneously…