openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
Single-cell foundation models predict durable CAR T response despite imperfect cell annotation
Leo Shen, Zhiliang Bai, Mingyu Yang, Na Li, Rong Fan
CD19 targeted chimeric antigen receptor (CAR) T cell therapy achieves high initial response rates in B cell acute lymphoblastic leukemia (B ALL), yet half of patients relapse within one year. Pre-infusion product composition decoded by single-cell RNA sequencing (scRNA-seq) carri…