openalexTranslational Oncology2026-07-23
Single-cell and spatial transcriptomics reveal SUV39H1 as a master epigenetic driver of immunosuppressive niche and stemness in bladder cancer
Yunpeng Li, Ling Wu, Jiaxu Shi, Li Wl, Jianguo Kuang, S H Li, et al.
Bladder cancer (BC) exhibits profound molecular heterogeneity and a highly dynamic tumor microenvironment, posing major challenges for effective therapy. In this study, we leveraged single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics, complemented by integrative mu…