arxiveess.IVcs.CVcs.LGphysics.optics2026-06-26
A Zero-Shot Deep Image Prior Framework for Denoising and Deconvolution in Fluorescence Microscopy
Xiangyu Qian, Jing Liu, Yunqing Tang, Luru Dai, Qiushi Li
Fluorescence microscopy images are degraded by noise and diffraction-induced blur, which compromise structural fidelity and limit quantitative analysis. Supervised deep learning methods achieve impressive restoration performance but require large-scale paired datasets that are di…