openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-23
Sensory experience and mTORC1 interplay orchestrates the maturation of cortical interneuron connectivity and tactile sensitivity
Clara A. Amegandjin, Maria-Isabel Carreño-Muñoz, Ruggiero Francavilla, Jorelle Linda Damo Kamda, M. Roussel, Antônia Sâmia Fernandes do Nascimento, et al.
ABSTRACT Sensory abnormalities are core features of neurodevelopmental disorders, including autism. Although interneuron dysfunction is hypothesized to contribute to these deficits, the underlying mechanisms remain unclear. Here, we demonstrate that mTORC1 dysregulation in parval…