crossrefInternational Journal of Molecular Sciences2026-05-08
Integrating Pharmacogenomics and Network Topology for Machine Learning Prediction of HLA-Associated Severe Cutaneous Adverse Drug Reactions
Tanaporn Ponduan, Arisara Kunsombut, Thummarat Paklao, Apichat Suratanee, Natapol Pornputtapong, Kitiporn Plaimas
Adverse drug reactions (ADRs) remain a major clinical challenge and a leading cause of morbidity and mortality worldwide. Among them, severe cutaneous adverse drug reactions (SCARs), including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), represent life-thr…