arxivcs.LGq-bio.GN2026-07-01
A Novel Machine Learning Approach for Central Nervous System Tumor Classification from DNA Methylation
Paulo R. Ferreira, Lucas Coutinho Freitas, Laís dos Santos Gonçalves, William Borges Domingues, Lucas Petitemberte de Souza, Mariana B. Michalowski, et al.
NA methylation profiling has become a powerful approach for central nervous system (CNS) tumor classification, yet important challenges remain regarding cross-cohort transferability, methodological correctness, and robust multiclass evaluation. In this work, we propose a novel an…