crossrefCancers2026-03-18
From LQ to AI-BED-Fx: A Unified Multi-Fraction Radiobiological and Machine-Learning Framework for Gamma Knife Radiosurgery Across Intracranial Pathologies
Răzvan Buga, Călin Gheorghe Buzea, Valentin Nedeff, Florin Nedeff, Diana Mirilă, Maricel Agop, et al.
Background: Gamma Knife radiosurgery (GKS) delivers highly conformal intracranial irradiation, yet clinical decision-making still relies predominantly on physical dose metrics that do not account for fractionation, dose rate, treatment time, or DNA repair. Classical radiobiologic…