semantic_scholarNAR Cancer
Cross-modal mapping of cancer stem-like cell plasticity using deep learning.
Debojyoti Chowdhury, Shreyansh Priyadarshi, Sayan Biswas, Bhavesh Neekhra, Debayan Gupta, Shubhasis Haldar
TL;DR: Applied to over 25 000 tumor profiles from The Cancer Genome Atlas, PREdiction of Clinical Outcomes from Genomics, tumor-relapse, and checkpoint inhibitor studies, ACSCeND reveals that CSC abundance strongly correlates with poor disease-free survival and reduced immunotherapy efficacy.
Cancer stem-like cells (CSCs) play a pivotal role in driving tumor heterogeneity, therapeutic resistance, and disease progression. Despite the power of single-cell RNA sequencing (scRNA-seq) to resolve intratumoral hierarchies, there remains a need for robust, scalable tools to c…