openalexFrontiers in Cell and Developmental Biology2026-07-24
Dynamic tumor microenvironment remodeling in cancer therapy resistance: molecular mechanisms and translational opportunities
Xiaoying Li, Shuang Dai, Dan Cao, Hou Wt
Therapeutic resistance remains a major obstacle in solid tumor management, arising not only from tumor cell-intrinsic alterations but also from dynamic remodeling of the tumor microenvironment (TME). Therapy-induced changes in stromal and immune cells, extracellular matrix (ECM)…