arxivcs.LG2026-07-06
Biologically Informed Deep Neural Networks for Multi-Omic Integration, Pathway Activity Inference and Risk Stratification in Cancer
Pedro Henrique da Costa Avelar, Le Ou-Yang, Min Wu, Sophia Tsoka
Integrating complex, multi-omics data presents significant challenges. Existing approaches often face a trade-off between model interpretability and representational capacity, with most either relying on post-hoc interpretation or use linear models that may overlook complex inter…