arxivq-bio.QMcs.LG2026-07-04
Trajectory Inference of Human Aging from Cross-Sectional DNA Methylation Data
Chandan Gupta, Syed Haider, Pietro Liò
DNA methylation (DNAm) serves as one of the most robust molecular biomarkers of biological aging. While conventional epigenetic clocks accurately predict chronological age from high-dimensional CpG profiles, they treat aging as a static regression task, meaning they can only outp…