Szczepan W. Baran

Hybrid mechanistic–machine learning PK/PD models with digital biomarkers: from cage to clinic

Szczepan W. Baran, Stefano Gaburro

Background Pharmacometric PK/PD models remain central to dose selection for first-in-human studies, therapeutic drug monitoring, and animal-to-human extrapolation of exposure–response relationships, but modern datasets, including digital biomarkers from continuous monitoring, omi…Read more