openalexNature Communications2026-07-23
Deciphering the initiation pathway of CagT4SS assembly by in vitro reconstitution of subcomplexes
Hoi Yee Chu, Chin Yu Mok, You-Rong Lin, Huawei Zhang, Takayuki Uchihashi, Shannon Wing Ngor Au
Abstract Cag type IV secretion system (CagT4SS) mediates the translocation of diverse substrates and is critical for the Helicobacter pylori pathogenesis. Its assembly is initiated by the central cylinder comprising CagX, CagY and CagM, however, the order and detailed mechanism r…