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Tianming Han

2 papers indexed

arxivcs.LGcs.AIq-bio.BM2026-07-15

SenCos-GEM: SENet-Calibrated and Law-of-Cosines-Constrained Geometry-Enhanced Molecular Representation for Property Prediction

Tianming Han, Li Zhang, Qi Zhao

Effective molecular representation learning is crucial for accurate molecular property prediction. Recently, numerous self-supervised learning (SSL) approaches leveraging 3D GNNs have been developed to capture comprehensive 3D structural information for drug discovery. However, e…

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arxivcs.LGcs.AI2026-07-14

Beyond SBDD: Geometric Deep Learning in Polypharmacology and Multi-target Drug Design

Tianming Han, Zhijie Pan, Wenchi Ge, Qi Zhao

The traditional "one drug, one target" paradigm of structure-based drug design (SBDD) frequently proves inadequate for treating multifactorial diseases such as cancer and neurodegenerative disorders, owing to compensatory signaling pathways and the emergence of drug resistance. W…

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