openalexScientific Reports2026-07-23
CleaveSmart: deciphering the puzzle of rational 10–23 DNAzyme selection through interpretable AI insights
Fatemeh Rahimpour, Fatemeh Javadi‐Zarnaghi, Elahe Mousavi, Vajihe Akbari
The 10–23 DNAzyme is a versatile platform for programmable RNA cleavage in gene regulation and diagnostics; however, its practical efficacy remains limited by the absence of precise selection criteria for optimal enzyme–substrate pairs. While machine learning (ML) offers a robust…