arxivcs.LGq-bio.GN2026-06-26
scKDGM: KAN-guided Dynamic Graph Masked Learning for Single-Cell RNA-seq Clustering
Jun Tang, Pengwei Hu, Sicong Gao, Jie Guo, Lun Hu, Xin Luo
Single-cell RNA sequencing (scRNA-seq) clustering is essential for identifying cell types, but high dimensionality, sparsity, dropout, and technical noise hinder robust expression representation and cell graph construction. Existing masked autoencoders mainly use expression recov…