openalexFrontiers in Immunology2026-07-23
Metabolic immune checkpoints in cancer: how tumor-derived metabolites shape immunotherapy resistance
Renjie Pan, Dongdong Chen, Y X Wu, 张兰成, J B Zhang, Junjie Li, et al.
Immune checkpoint blockade has transformed cancer therapy, yet many tumors remain intrinsically resistant or acquire resistance after initial response. Increasing evidence indicates that this failure is not determined solely by PD-1, PD-L1, CTLA-4, or T-cell exhaustion, but also…