arxivcs.LGq-bio.MN2026-07-21
PertReason: A Knowledge-Grounded Benchmark and Framework for Cell-State-Conditioned Mechanistic Reasoning of Perturbation Effects
Dongkwan Kim, Yiming Gao, Yining Yang, Yang Shen
Evaluating machine learning in scientific domains requires separating correct predictions from correct reasons under realistic distribution shifts. We introduce PertReason, a knowledge-grounded benchmark and framework suite for cell-state--conditioned reasoning about perturbation…