openalexbioRxiv (Cold Spring Harbor Laboratory)2026-07-24
Beyond Expression Prediction: Benchmarking Differential Expression Classification in Single-Cell Perturbation Models
Junwei Sun, Yuxun He, Ouyang Zhu, Yiqun T. Chen
Accurate predictions of transcriptomic responses to genetic perturbations could unlock our understanding of gene functions and regulatory networks. While a growing number of methods and benchmarks target this task, existing evaluations focus on mean expression accuracy alone. Thi…