crossrefInternational Journal of Molecular Sciences2026-05-10
An Integrated Machine-Learning and Reverse Network-Pharmacology Pipeline Reveals JUN/C3 Candidate Biomarkers and an Anti-Fibrotic Mechanism of Resveratrol via MAPK/JNK Signaling in Chronic Kidney Disease
Yuan Cai, Xiaolong Feng, Xinru Tao, Penghui Li, Jiaqin Liu, Ping’an Liu, et al.
Chronic kidney disease (CKD) lacks highly specific early diagnostic biomarkers and safe, effective therapeutic options. To address this, we integrated multi-cohort transcriptomics, bioinformatics, and machine learning with reverse network pharmacology, molecular docking, molecula…