arxivcs.AI2026-06-30
CryoACE: An Atom-centric Framework for Accurate and Automated Model Building in Cryo-EM
Minzhang Li, Mingrui Li, Weichen Qin, Qihe Chen, Sixian Shen, Yuan Pei, et al.
Protein automodeling from cryo-EM density maps faces unique challenges in enforcing physicochemical validity and managing conformational heterogeneity. Current solvers are often limited to static predictions or require computationally intensive heuristic searches. We present Cryo…