Zhengwei Xie

Modeling Cell-Cycle-Aware Single-Cell Drug Perturbation Responses

Dingping Zhao, Jie Lin, Feng Xu, Zhengwei Xie

Single-cell drug perturbation models should capture transcriptional response magnitude and whether a treatment changes the proliferative state of the cell. This is difficult because cell-cycle variation is often treated as a nuisance factor, and benchmark processing rarely makes…Read more