Zixiang Yin

Structure-Regularized Interpretable TCR-Epitope Prediction

Jiarui Li, Zixiang Yin, Yunbei Zhang, Janet Wang, Samuel J. Landry, Zhengming Ding, et al.

T cell receptor (TCR)-epitope binding prediction is essential for understanding adaptive immunity and developing immunotherapies. Existing sequence- and structure-based models often generalize poorly to unseen epitopes and provide limited interpretability. Furthermore, the impact…Read more