The expression of certain genes and proteins in brain tumors, particularly gliomas, presents potential therapeutic targets and biomarkers. One of such genes encodes the protein PINK1 (PTEN-induced Kinase 1), which has been primarily studied due to its mutations being linked to Parkinson’s disease (PD). Additionally, epidemiological studies have observed a reduced risk of developing certain types of cancer in patients with neurodegenerative diseases and vice versa. The GPR55 receptor (G protein-coupled receptor 55) exhibits pro-oncogenic properties, and its expression correlates with tumor aggressiveness and the activation of the MAPK/ERK signaling pathway. This review would aim to provide an overview of the current understanding of the relationship between PINK1 and GPR55 proteins in glioma pathophysiology and explore the potential use of plant extracts as a therapeutic alternative to regulate their expression.
Increasing importance of patient-generated real-world data for healthcare policy decisions about medicinal products: Volume III Real-world data (RWD) and the real-world evidence (RWE) derived from it have moved from the margins to the centre of decision-making about medicinal pro…
Alcohol use disorders (AUD) are major public health issues, with a significant negative impact on the health system and the economy. Unfortunately, only a handful of pharmacotherapeutic agents are available to treat patients with AUD. Notably, these medications have limited effic…
Background Matrine and oxymatrine are bioactive alkaloids from Sophora species with reported anti-inflammatory and antioxidant effects in ulcerative colitis (UC). However, their overall efficacy has not been systematically evaluated. Methods Databases including PubMed, EMBASE, We…
Background Conventional dual antiplatelet therapy (DAPT) post percutaneous coronary intervention (PCI) comprises aspirin and a P2Y 12 inhibitor. However, aspirin increases gastrointestinal and bleeding risks. Indobufen, a reversible COX-1 inhibitor, may offer a safer alternative.…
Crotamine is a low-molecular-weight cationic polypeptide isolated from Crotalus durissus terrificus snake venom, classified as a non-enzymatic toxin with distinctive structural and functional properties. This toxin also exhibits characteristics of a cell-penetrating peptide, owin…
Background The optimal vasopressor-escalation strategy after norepinephrine in septic shock remains uncertain, with randomized trials showing no clear winner and observational data suggesting severity-dependent effects. We characterized severity-stratified heterogeneity for addin…