openalexFrontiers in Immunology2026-07-24
Aerobic exercise combined with FK866 ameliorates Alzheimer’s disease-like pathology in APP/PS1 mice with NAMPT abnormality
Chang Sun, Tinggui Zhang, Bei Fan, Xi Zhang, Na Zhao
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD + salvage pathway, has emerged as an important regulatory node linking metabolic homeostasis to neuroinflammatory responses. However, although pharmacological inhibition of NAMPT may attenuate inf…