crossrefFrontiers in Nutrition2026-07-06
Neuroprotective potential of the natural polyphenol Procyanidin B2 in spinal cord injury: a comprehensive study utilizing machine learning, network pharmacology, and in vivo validation
Chunyu Xiang, Yang Liu, Rui Gu, Wanguo Liu, Jingwei Shi
Background The secondary injury cascade following spinal cord injury (SCI) drives severe inflammation and tissue destruction. Although the natural polyphenol Procyanidin B2 (PCB2) has well-documented neuroprotective properties, its specific therapeutic efficacy in SCI, as well as…